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KMID : 1123920070210051291
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Korean Journal of Oriental Physiology and Pathology
2007 Volume.21 No. 5 p.1291 ~ p.1296
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Influence of Prenatal Noise and Music on the Expressions of c-Fos and Nitric Oxide Synthase in the Hippocampus of Rat Pups
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Kim Su-Mee
Lee Sam-Jun
Kim Hong
Baek Seung-Soo
Lee Jin-Woo
Kim Young-Sick
Kim Sung-Eun
Shin Mal-Soon
Kim Chang-Ju
Lee Choong-Yeol
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Abstract
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The expressions of c-Fos and nitric oxide synthase (NOS) represent neuronal activity and play’ a crucial role in the shaping of the development of brain. During the late pregnancy, stresses may influence neuronal activity of prenatal rats. In the present study, the effects of prenatal noise and music on the expressions of c-Fos and NOS in the hippocampus of rat pups were investigated. Exposure to the noise during pregnancy decreased c-Fos and NOS expressions in the hippocampus of rat pups, whereas exposure to music during pregnancy increased c-Fos and NOS expressions in the hippocampus of rat pups. The present results show that prenatal music stimulation may increase neuronal activity of rat offspring, whereas exposure to noise during pregnancy may reduce the neuronal activity of offspring. The present study suggests that prenatal stimuli including noise and music could affect the fetal brain development.
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KEYWORD
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Prenatal noise, prenatal music, c-Fos, nitric oxide synthase, hippocampus
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